98008-66-3Relevant articles and documents
HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS
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Paragraph 0508-0509, (2021/09/11)
The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
MULTIFUNCTIONAL RADICAL QUENCHERS
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Page/Page column 51-52, (2014/05/07)
The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers
Lee, Hyung Kook,Lee, Yun Suk,Roh, Eun Joo,Rhim, Hyewhon,Lee, Jae Yeol,Shin, Kye Jung
scheme or table, p. 4424 - 4427 (2009/04/06)
We have synthesized and evaluated α,α′-disubstituted phenylacetate derivatives that were designed as T-type calcium channel blockers. Among them, compound 10e (IC50 = 8.17 ± 0.48 nM) showed the most potent T-type calcium current blocking activity and higher potency than Mibefradil (IC50 = 1.34 ± 0.49 μM). The PK profile and subtype selectivity over L-type calcium channel were satisfied for further animal assay using disease model.