5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

Base Information

Chemical Name:5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester
CAS No.:1025983-07-6
Molecular Formula:C₂₉H₃₂ClNO₆
Molecular Weight:526.029
Hs Code.:

5-methyl-4-oxo-hexanoic acid 3-<i>tert</i>-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1<i>H</i>-indol-5-yl ester

Synonyms:5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

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Chemical Property of 5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

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Technology Process of 5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

There total 5 articles about 5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2854-10-6
levulinic acid t-butyl ester

: 1025983-07-6
5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / AcONa / acetic acid / 2 h / Heating

2.1: tBuOK / tetrahydrofuran / 0.33 h

2.2: 100 percent / tetrahydrofuran / 11 h

3.1: H₂; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr

4.1: DCC; DMAP / CH₂Cl₂ / 12 h

With dmap; potassium tert-butylate; hydrogen; sodium acetate; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1021/jm000483h

Reference yield:

: 52068-30-1,55974-70-4
4-benzyloxyphenylhydrazine hydrochloride

: 1025983-07-6
5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / AcONa / acetic acid / 2 h / Heating

2.1: tBuOK / tetrahydrofuran / 0.33 h

2.2: 100 percent / tetrahydrofuran / 11 h

3.1: H₂; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr

4.1: DCC; DMAP / CH₂Cl₂ / 12 h

With dmap; potassium tert-butylate; hydrogen; sodium acetate; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1021/jm000483h

Reference yield:

: 346424-35-9
t-butyl 5-benzyloxy-2-methyl indole acetate

: 1025983-07-6
5-methyl-4-oxo-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tBuOK / tetrahydrofuran / 0.33 h

1.2: 100 percent / tetrahydrofuran / 11 h

2.1: H₂; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr

3.1: DCC; DMAP / CH₂Cl₂ / 12 h

With dmap; potassium tert-butylate; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm000483h