methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate

Base Information

• Chemical Name: methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate
• CAS No.: 443920-29-4
• Molecular Formula: C₁₃H₁₈O₅
• Molecular Weight: 254.283
• Mol file: 443920-29-4.mol

Synonyms:methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate

Chemical Property of methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate

There total 4 articles about methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-(3,4-dimethoxyphenyl)-4-oxobutanoate (14563-40-7) → methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate (443920-29-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2585.74 Torr;

DOI:10.1016/S0040-4020(03)00476-9

Reference yield: 81.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate (443920-29-4)

Guidance literature:

With Hf₁₂O₈(OH)8(OH)6⁽¹²⁺⁾*12C₁₂H₅F₅N^(1-)*6C₂₄H₁₄N₂O₄^(2-)*6Ir⁽³⁺⁾*6CF₃O₃S^(1-); bis(2-methoxyethyl) 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/jacs.1c10180

Reference yield:

1,2-dimethoxybenzene (91-16-7) → methyl 4-(3,4-dimethoxyphenyl)-4-hydroxybutanoate (443920-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81.4 percent / AlCl₃ / nitrobenzene / 3 h / Heating

2: 5 g / diethyl ether

3: 99 percent / H₂ / Pd/C / ethanol / 2585.74 Torr

With aluminium trichloride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; nitrobenzene; 1: Friedel-Crafts reaction;

DOI:10.1016/S0040-4020(03)00476-9

upstream raw materials:

methyl 4-(3,4-dimethoxyphenyl)-4-oxobutanoate

1,2-dimethoxybenzene

3-(3,4-dimethoxybenzoyl)propionic acid

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

methyl 4-(3,4-dimethoxyphenyl)-3-hydroxymethylbutanoate

3-(3,4-dimethoxyphenyl)methyl-2-buten-1,4-olide

4-[(3,4-dimethoxyphenyl)methyl]dihydrofuran-2-one