4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Base Information

Chemical Name:4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone
CAS No.:79619-07-1
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

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Chemical Property of 4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

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Technology Process of 4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

There total 14 articles about 4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 67-56-1
methanol

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 79619-07-1
4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Guidance literature:: With sodium methylate; for 21h; Ambient temperature;
DOI:10.1021/jo00349a006

Reference yield: 70.0%

: 1445-45-0
Trimethyl orthoacetate

: 79619-02-6
3-(Hydroxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-5,6-dihydro-2-pyridinone

: 79619-07-1
4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Guidance literature:: With Trimethylacetic acid; In diethylene glycol dimethyl ether; 1.) 8 h, 165 deg C, 2.) 16 h, reflux;
DOI:10.1021/jo00338a003

Reference yield:

: 79618-90-9
(E)-ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate

: 79619-07-1
4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) NaOEt / 1.) EtOH, 2.) EtOH, 3 h, reflux

2: H₂, ethanolic HCl / PtO₂ / 12 h / 20 - 26 °C / 2068.6 - 2585.7 Torr

3: toluene / 2 h / Heating

4: 1.) Me₃OBF₄, 2.) NaBH₄ / 1.) CH₂Cl₂, 24 h, room temperature, 2.) EtOH, 12 h, 23 deg C

5: 94 percent / H₂ / 10percent Pd/C / ethanol; H₂O / 24 h / 20 - 26 °C / 2068.6 - 2585.7 Torr

7: 55 percent / SeO₂ / chlorobenzene / 1.17 h / 100 °C

8: 85 percent / 16 h / Ambient temperature

9: K₂CO₃, MeOH / 22 h / Ambient temperature

10: 70 percent / pivalic acid / bis-(2-methoxy-ethyl) ether / 1.) 8 h, 165 deg C, 2.) 16 h, reflux

With hydrogenchloride; methanol; sodium tetrahydroborate; selenium(IV) oxide; hydrogen; sodium ethanolate; trimethoxonium tetrafluoroborate; potassium carbonate; Trimethylacetic acid; platinum(IV) oxide; palladium on activated charcoal; In ethanol; diethylene glycol dimethyl ether; water; chlorobenzene; toluene;
DOI:10.1021/jo00338a003