(3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

Base Information

Chemical Name:(3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol
CAS No.:1159006-38-8
Molecular Formula:C₁₆H₂₇IO₃
Molecular Weight:394.293
Hs Code.:

Synonyms:(3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

Suppliers and Price of (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

Chemical Property:

Purity/Quality:: 95-4210%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

There total 1 articles about (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914922-88-6
C₁₇H₃₅NO₃Si

: 1159006-38-8
(3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water; tert-butyl alcohol / 0 °C / Inert atmosphere

2: sodium periodate / tetrahydrofuran; water; tert-butyl alcohol / 6 h / 0 - 20 °C

3: chromium dichloride; triethylamine; nickel dichloride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Glovebox

4: silver trifluoromethanesulfonate; silver(II) oxide

5: tetrahydrofuran / 1 h / -20 - 20 °C / Inert atmosphere

6: triethylamine; hydrazine hydrate / ethanol / 2.5 h / 60 - 65 °C

7: triethylamine; iodine / diethyl ether / 0 - 20 °C

8: hydrogenchloride / methanol; isopropyl alcohol / 3 h / 0 - 20 °C / Inert atmosphere

With chromium dichloride; hydrogenchloride; silver(II) oxide; sodium periodate; osmium(VIII) oxide; hydrazine hydrate; iodine; silver trifluoromethanesulfonate; 4-methylmorpholine N-oxide; triethylamine; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; isopropyl alcohol; tert-butyl alcohol;

Reference yield: 83.0%

: 1159006-38-8
(3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol

: 3282-30-2
pivaloyl chloride

: 157322-47-9
3-((2S,5S)-5-((3R,5R)-3-hydroxy-6-iodo-5-methylhept-6-en-1-yl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate

Guidance literature:: (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol; With 2,4,6-trimethyl-pyridine; dmap; at 0 ℃; for 0.5h; Inert atmosphere;

pivaloyl chloride; at 20 ℃; for 0.75h; Inert atmosphere;