Technology Process of 4-(4-methoxy-3,6-dioxo-5-tridecylcyclohexa-1,4-dienylamino)butanoic acid
There total 8 articles about 4-(4-methoxy-3,6-dioxo-5-tridecylcyclohexa-1,4-dienylamino)butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methoxybenzene; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/np3007099
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -40 - 0 °C
1.2: 15 h / 20 °C / Inert atmosphere
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3.5 h / -7 - 20 °C / Cooling with ice
3.1: sodium hydrogencarbonate / ethanol / 27 h / 45 °C / Inert atmosphere
4.1: potassium carbonate / acetone / Reflux
5.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; ammonium cerium (IV) nitrate; sodium hydrogencarbonate; potassium carbonate; methoxybenzene; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/np3007099
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium cerium (IV) nitrate / acetonitrile; water / 3.5 h / -7 - 20 °C / Cooling with ice
2: sodium hydrogencarbonate / ethanol / 27 h / 45 °C / Inert atmosphere
3: potassium carbonate / acetone / Reflux
4: trifluoroacetic acid; methoxybenzene / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
ammonium cerium (IV) nitrate; sodium hydrogencarbonate; potassium carbonate; methoxybenzene; trifluoroacetic acid;
In
ethanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/np3007099
