Morpholine, 4-(p-methoxybenzoyl)-

Base Information

• Chemical Name: Morpholine, 4-(p-methoxybenzoyl)-
• CAS No.: 7504-58-7
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• NSC Number: 407868
• UNII: CCH6F4QD52
• DSSTox Substance ID: DTXSID80226004
• Nikkaji Number: J42.345I
• Mol file: 7504-58-7.mol

Synonyms:Morpholine, 4-(4-methoxybenzoyl)-;Morpholine, 4-(p-methoxybenzoyl)-;4-(4-methoxybenzoyl)morpholine;7504-58-7;4-(p-Methoxybenzoyl)morpholine;p-Anisic acid, morpholide;NSC 407868;BRN 1214017;CCH6F4QD52;(4-methoxyphenyl)(morpholin-4-yl)methanone;AI3-22703;NSC-407868;NSC407868;UNII-CCH6F4QD52;SCHEMBL9792247;DTXSID80226004;MORPHOLINE, 4-P-ANISOYL-;STK412984;(4-methoxyphenyl)(morpholino)methanone;AKOS003240867;N-(4-METHOXYBENZOYL)MORPHOLINE;LS-93092;(4-METHOXYPHENYL)-4-MORPHOLINYLMETHANONE;METHANONE, (4-METHOXYPHENYL)-4-MORPHOLINYL-

Chemical Property of Morpholine, 4-(p-methoxybenzoyl)-

Chemical Property:

• Vapor Pressure: 2.25E-06mmHg at 25°C
• Boiling Point: 392.7°C at 760 mmHg
• Flash Point: 191.3°C
• PSA: 38.77000
• Density: 1.167g/cm³
• LogP: 1.10550
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 221.10519334
• Heavy Atom Count: 16
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

4-(4-methoxybenzoyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N2CCOCC2

Technology Process of Morpholine, 4-(p-methoxybenzoyl)-

There total 48 articles about Morpholine, 4-(p-methoxybenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-methoxy-benzaldehyde (123-11-5) → N-(4-methoxybenzoyl)morpholine (7504-58-7)

Guidance literature:

With bromobenzene; potassium carbonate; triphenylphosphine; palladium diacetate; In 1,2-dimethoxyethane; for 24h; Heating;

DOI:10.1055/s-1983-30388

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 4-methoxybenzoic acid (100-09-4) → N-(4-methoxybenzoyl)morpholine (7504-58-7)

Guidance literature:

With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine; In tetrahydrofuran; dichloromethane; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2013.03.021

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 1-bromo-4-methoxy-benzene (104-92-7) + carbon monoxide (201230-82-2) → N-(4-methoxybenzoyl)morpholine (7504-58-7)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; dicobalt octacarbonyl; In tert-Amyl alcohol; for 48h; under 1520.1 Torr; Irradiation;

DOI:10.1039/d0sc02178d

upstream raw materials:

morpholine

Anisoyl-4-tolylsulfon

4-methoxy-benzaldehyde

N-(4-methoxy-thiobenzoyl)-morpholine

Downstream raw materials:

5-(4-Methoxy-benzoyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

2-(4-Methoxybenzoyl)-5-benzylpyrrole

4-(p-methoxyselenobenzoyl)morpholine

5,5'-bis(p-methoxybenzoyl)-3,3',4,4'-tetraethyl-2,2'-bipyrrole