C₂₈H₂₇FN₂O₃

Base Information

Chemical Name:C₂₈H₂₇FN₂O₃
CAS No.:1359022-17-5
Molecular Formula:C₂₈H₂₇FN₂O₃
Molecular Weight:458.532
Hs Code.:

C<sub>28</sub>H<sub>27</sub>FN<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₈H₂₇FN₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₈H₂₇FN₂O₃

Chemical Property:

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Technology Process of C₂₈H₂₇FN₂O₃

There total 11 articles about C₂₈H₂₇FN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 513-38-2
Isobutyl iodide

: 1359022-16-4
C₂₄H₁₉FN₂O₃

: 1359022-17-5
C₂₈H₂₇FN₂O₃

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 394-04-7
5-fluoro-2-methoxybenzoic acid

: 1359022-17-5
C₂₈H₂₇FN₂O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 2 h / -78 °C

1.2: 2 h / 25 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C

2.2: 12 h / 25 °C

3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

4.1: bromine; acetic acid / 2 h / 20 °C

5.1: potassium carbonate / acetone / 3 h / 0 - 50 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.17 h / -78 °C

6.2: 1 h / -20 °C

7.1: toluene-4-sulfonic acid / Reflux

8.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -50 - 0 °C

8.3: 16 h / 20 °C

9.1: ethyl acetate; tert-butyl alcohol / 1 h / 20 °C

9.2: 12 h / 70 °C

9.3: 7 h / 20 °C

10.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

With oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; bromine; sec.-butyllithium; isopropylmagnesium chloride; boron tribromide; sodium hydride; potassium carbonate; acetic acid; lithium chloride; lithium diisopropyl amide; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; dichloromethane; cyclohexane; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 1207283-54-2
phenyl 3-fluoro-6-methoxy-2-methylbenzoate

: 1359022-17-5
C₂₈H₂₇FN₂O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

2.1: bromine; acetic acid / 2 h / 20 °C

3.1: potassium carbonate / acetone / 3 h / 0 - 50 °C

4.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.17 h / -78 °C

4.2: 1 h / -20 °C

5.1: toluene-4-sulfonic acid / Reflux

6.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -50 - 0 °C

6.3: 16 h / 20 °C

7.1: ethyl acetate; tert-butyl alcohol / 1 h / 20 °C

7.2: 12 h / 70 °C

7.3: 7 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

With bromine; isopropylmagnesium chloride; boron tribromide; sodium hydride; potassium carbonate; acetic acid; lithium chloride; lithium diisopropyl amide; toluene-4-sulfonic acid; In tetrahydrofuran; hexanes; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;