N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine

Base Information

• Chemical Name: N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine
• CAS No.: 169882-77-3
• Molecular Formula: C₁₇H₂₀BrN₃O₂
• Molecular Weight: 378.269
• Mol file: 169882-77-3.mol

Synonyms:N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine

Chemical Property of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine

There total 5 articles about N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 2-((2-bromo-4-(1-methylethyl)-phenyl)-ethylamino)-6-methyl-4-pyrimidinaminecarboxylate → N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine (169882-77-3)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield: 95.0%

methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate (169880-48-2) → N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine (169882-77-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 18h; Heating / reflux;

Reference yield:

2-bromo-4-isopropylaniline (51605-97-1) → N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-carboxy-6-methylpyrimidinamine (169882-77-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / dioxane / 24 h / Heating

2: 55 percent / NaH / dimethylformamide / 5 h

3: aq. NaOH / ethanol / 7 h / Heating

With sodium hydroxide; sodium hydride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation / 3: Hydrolysis;

DOI:10.1016/S0968-0896(99)00182-0

upstream raw materials:

methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

2-bromo-4-isopropylaniline

methyl 2-chloro-6-methylpyrimidine-4-carboxylate

2-(N-(2-bromo-4-(2-propyl)phenyl)amino)-4-carbomethoxy-6-methylpyrimidinamine

Downstream raw materials:

N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-acetyl-6-methylpyrimidinamine