4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

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Chemical Name:4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester
CAS No.:194738-02-8
Molecular Formula:C₃₃H₃₈FN₃O₄
Molecular Weight:559.681
Hs Code.:

Synonyms:4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

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Chemical Property of 4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

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Technology Process of 4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

There total 8 articles about 4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 148583-64-6
N-(3-(chloromethyl)benzoyl)piperidine

: 194738-01-7
4-Fluoro-benzoic acid 3-isopropoxy-4-piperazin-1-yl-phenyl ester

: 194738-02-8
4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

Guidance literature:: With sodium carbonate; In ethyl acetate;
DOI:10.1016/S0960-894X(97)00336-3

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 194738-02-8
4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / K₂CO₃ / dimethylformamide

2: 87 percent / KOH, Aliquat 336

3: 74 percent / TMSI

4: 73 percent / Et₃N / ethyl acetate

5: 99 percent / H₂ / Pd/C

6: 33 percent

7: 30 percent / Na₂CO₃ / ethyl acetate

With potassium hydroxide; trimethylsilyl iodide; hydrogen; Aliquat 336; sodium carbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00336-3

Reference yield:

: 28987-46-4
4-fluoro-1-nitro-2-(propan-2-yloxy)benzene

: 194738-02-8
4-Fluoro-benzoic acid 3-isopropoxy-4-{4-[3-(piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / KOH, Aliquat 336

2: 74 percent / TMSI

3: 73 percent / Et₃N / ethyl acetate

4: 99 percent / H₂ / Pd/C

5: 33 percent

6: 30 percent / Na₂CO₃ / ethyl acetate

With potassium hydroxide; trimethylsilyl iodide; hydrogen; Aliquat 336; sodium carbonate; triethylamine; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0960-894X(97)00336-3