methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

Base Information

Chemical Name:methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate
CAS No.:1616854-62-6
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

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Chemical Property of methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

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Technology Process of methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

There total 7 articles about methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616851-46-7
tert-butyl 4-(3-(2-methoxy-2-oxoethyl)-3-methyl-2-oxoindolin-1-yl)piperidine-1-carboxylate

: 100-52-7
benzaldehyde

: 1616854-62-6
methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

Guidance literature:: tert-butyl 4-(3-(2-methoxy-2-oxoethyl)-3-methyl-2-oxoindolin-1-yl)piperidine-1-carboxylate; benzaldehyde; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 35 ℃; for 2h;

Reference yield:

: 30095-98-8
methyl (2-nitrophenyl)acetate

: 1616854-62-6
methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3.1: acetic acid / methanol / 1 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: hydrogenchloride / methanol; water / 0.5 h / 20 °C

6.1: dichloromethane / 1 h / 20 °C

6.2: 2 h / 35 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 30096-07-2
methyl α-methyl-2-nitrobenzeneacetate

: 1616854-62-6
methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

2.1: acetic acid / methanol / 1 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: hydrogenchloride / methanol; water / 0.5 h / 20 °C

5.1: dichloromethane / 1 h / 20 °C

5.2: 2 h / 35 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;