2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Base Information

Chemical Name:2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide
CAS No.:1616851-48-9
Molecular Formula:C₂₄H₂₉N₃O₂
Molecular Weight:391.513
Hs Code.:

Synonyms:2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

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Chemical Property of 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Chemical Property:

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Technology Process of 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

There total 8 articles about 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1616854-62-6
methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate

: 74-89-5
methylamine

: 1616851-48-9
2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: With methanol; at 80 ℃; Sealed tube;

Reference yield:

: 30095-98-8
methyl (2-nitrophenyl)acetate

: 1616851-48-9
2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3.1: acetic acid / methanol / 1 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: hydrogenchloride / methanol; water / 0.5 h / 20 °C

6.1: dichloromethane / 1 h / 20 °C

6.2: 2 h / 35 °C

7.1: methanol / 80 °C / Sealed tube

With hydrogenchloride; methanol; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 30096-07-2
methyl α-methyl-2-nitrobenzeneacetate

: 1616851-48-9
2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

2.1: acetic acid / methanol / 1 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: hydrogenchloride / methanol; water / 0.5 h / 20 °C

5.1: dichloromethane / 1 h / 20 °C

5.2: 2 h / 35 °C

6.1: methanol / 80 °C / Sealed tube

With hydrogenchloride; methanol; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;