2-Methyl-4-chlor-6-methoxy-pyrimidin

Base Information

• Chemical Name: 2-Methyl-4-chlor-6-methoxy-pyrimidin
• CAS No.: 89466-39-7
• Molecular Formula: C₆H₇ClN₂O
• Molecular Weight: 158.587
• Hs Code.: 2933599590
• Mol file: 89466-39-7.mol

Synonyms:4-chloro-6-methoxy-2-methylpyrimidine

Chemical Property of 2-Methyl-4-chlor-6-methoxy-pyrimidin

Chemical Property:

• Vapor Pressure: 0.159mmHg at 25°C
• Boiling Point: 77-78℃ (8 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6-methoxy-2-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-4-chlor-6-methoxy-pyrimidin

There total 2 articles about 2-Methyl-4-chlor-6-methoxy-pyrimidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-2-methylpyrimidine (1780-26-3) + sodium methylate (124-41-4) → 4-chloro-6-methoxy-2-methylpyrimidine (89466-39-7)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1002/(SICI)1096-9063(199606)47:2<103::AID-PS396>3.0.CO;2-Z

Reference yield:

→ 4-chloro-6-methoxy-2-methylpyrimidine (89466-39-7)

Guidance literature:

2-Methyl-4,6-dichlorpyrimidin, NaOMe/MeOH, reflux;

Reference yield: 85.0%

2-Methylphenylboronic acid (16419-60-6) + 4-chloro-6-methoxy-2-methylpyrimidine (89466-39-7) → 4-methoxy-2-methyl-6-(2-methylphenyl)pyrimidine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; isopropyl alcohol; at 83 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.3987/COM-18-13956

upstream raw materials:

2,4-dichloro-2-methylpyrimidine

sodium methylate

Downstream raw materials:

6-methoxy-2-methylpyrimidine-4-carbonitrile