[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester

Base Information

• Chemical Name: [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester
• CAS No.: 153275-21-9
• Molecular Formula: C₃₄H₄₃N₃O₃
• Molecular Weight: 541.734
• Mol file: 153275-21-9.mol

Synonyms:[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester

Chemical Property of [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester

There total 16 articles about [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-allyloxybenzoate (35750-24-4) → [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester (153275-21-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 90 percent / 2,6-di-tert-butyl-4-methylphenol (BHT) / various solvent(s) / Heating

2: 87 percent / K₂CO₃ / acetone / Heating

3: 94 percent / 2,6-di-tert-butyl-4-methylphenol (BHT) / various solvent(s) / Heating

4: 97 percent / Et₃N, DMAP / CH₂Cl₂

5: 90 percent / H₂ / 5percent Rh/C / ethanol

6: 92 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

7: 82 percent / Ph₃P, DEAD / tetrahydrofuran / 0 °C

8: 93 percent / n-Bu₄NF / tetrahydrofuran

9: K₂CO₃ / acetone / Heating

With dmap; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; acetone;

DOI:10.1021/jm00075a033

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester (153275-21-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 89 percent / K₂CO₃ / acetone / Heating

2: 90 percent / 2,6-di-tert-butyl-4-methylphenol (BHT) / various solvent(s) / Heating

3: 87 percent / K₂CO₃ / acetone / Heating

4: 94 percent / 2,6-di-tert-butyl-4-methylphenol (BHT) / various solvent(s) / Heating

5: 97 percent / Et₃N, DMAP / CH₂Cl₂

6: 90 percent / H₂ / 5percent Rh/C / ethanol

7: 92 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

8: 82 percent / Ph₃P, DEAD / tetrahydrofuran / 0 °C

9: 93 percent / n-Bu₄NF / tetrahydrofuran

10: K₂CO₃ / acetone / Heating

With dmap; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; acetone;

DOI:10.1021/jm00075a033

Reference yield:

methyl 3-allyl-4-hydroxybenzoate (53596-60-4) → [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenoxy]-m-tolyl-acetic acid ethyl ester (153275-21-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 87 percent / K₂CO₃ / acetone / Heating

2: 94 percent / 2,6-di-tert-butyl-4-methylphenol (BHT) / various solvent(s) / Heating

3: 97 percent / Et₃N, DMAP / CH₂Cl₂

4: 90 percent / H₂ / 5percent Rh/C / ethanol

5: 92 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

6: 82 percent / Ph₃P, DEAD / tetrahydrofuran / 0 °C

7: 93 percent / n-Bu₄NF / tetrahydrofuran

8: K₂CO₃ / acetone / Heating

With dmap; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; acetone;

DOI:10.1021/jm00075a033

upstream raw materials:

ethyl α-bromo-3-methylphenylacetate

5,7-dimethyl-2-ethyl-3-[(4-hydroxy-3,5-dipropylphenyl)methyl]-3H-imidazo[4,5-b]pyridine

5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

ethyl 2-(2,6-Dipropyl-4-Bromomethyl-Phenoxy)-2-(3-Methylphenyl)Acetate