N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine

Base Information

• Chemical Name: N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine
• CAS No.: 1388891-59-5
• Molecular Formula: C₁₈H₂₄N₄S
• Molecular Weight: 328.481

Synonyms:N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine

Chemical Property of N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine

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Technology Process of N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine

There total 4 articles about N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yl]amino)cyclohexan-1-one (1388893-30-8) + azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0) → N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-amine (1388891-59-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-amine (1388891-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonia / methanol / 8 h / 0 - 10 °C

1.2: 0 - 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 60 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With hydrogenchloride; ammonia; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

1,4-dioxaspiro[4.5]decan-8-amine (97096-16-7) → N-[4-(azetidin-1-yl)cycIohexyl]-7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-amine (1388891-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 60 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexan-1-one

azetidine hydrochloride

cyclohexanedione monoethylene ketal

1,4-dioxaspiro[4.5]decan-8-amine

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