C₁₆H₁₆O₃S

Base Information

• Chemical Name: C₁₆H₁₆O₃S
• CAS No.: 101169-30-6
• Molecular Formula: C₁₆H₁₆O₃S
• Molecular Weight: 288.367
• Mol file: 101169-30-6.mol

Synonyms:C₁₆H₁₆O₃S

Chemical Property of C₁₆H₁₆O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₆H₁₆O₃S

There total 2 articles about C₁₆H₁₆O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(4-methoxyphenyl)oxirane (6388-72-3) + sodium 4-methylbenzenesulfinate (824-79-3) → C16H16O3S (101169-30-6) + 1-methoxy-4-(1-tosylvinyl)benzene (1372861-74-9)

Guidance literature:

With water; lithium bromide; at 80 - 90 ℃; for 8h; regioselective reaction;

DOI:10.1039/c2gc16664j

Reference yield: 73.0%

4-Methoxystyrene (637-69-4,24936-44-5) + 3-(trifluoromethyl)phenyl 4-methylbenzenesulfonate (131086-40-3) → C16H16O3S (101169-30-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; Irradiation;

DOI:10.1039/C8SC02769B

Reference yield: 72.0%

C16H16O3S (101169-30-6) + 3-benzylidene acetylacetone (4335-90-4) → 1-((2R*,6R*)-4-hydroxy-6-(4-methoxyphenyl)-2-phenyl-1-tosyl-1,2,5,6-tetrahydropyridin-3-yl)ethan-1-one

Guidance literature:

3-benzylidene acetylacetone; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.666667h; Inert atmosphere;

C₁₆H₁₆O₃S; In tetrahydrofuran; at -50 ℃; for 4h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2021.132285

upstream raw materials:

2-(4-methoxyphenyl)oxirane

sodium 4-methylbenzenesulfinate

4-Methoxystyrene

3-(trifluoromethyl)phenyl 4-methylbenzenesulfonate