tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate
CAS No.:1462921-16-9
Molecular Formula:C₁₆H₁₈ClIN₂O₄
Molecular Weight:464.687
Hs Code.:

Synonyms:tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

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Chemical Property of tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

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Technology Process of tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

There total 4 articles about tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1462921-15-8
4-acetyl-6-chloro-3-hydroxy-2-iodobenzonitrile

: 1462921-16-9
tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

Guidance literature:: 2-(N-tert-butoxycarbonylamino)ethanol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 0.25h; Cooling with ice;

4-acetyl-6-chloro-3-hydroxy-2-iodobenzonitrile; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

: 2732-80-1
2-bromo-1-chloro-4-methoxybenzene

: 1462921-16-9
tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / carbon disulfide / 1 h / Reflux

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

3.1: N-iodo-succinimide; acetic acid / acetic acid; ethyl acetate / 18 h / 80 °C

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.25 h / Cooling with ice

4.2: 20 °C / Cooling with ice

With aluminum (III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; diethylazodicarboxylate; In tetrahydrofuran; carbon disulfide; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1154415-17-4
1-(4-bromo-5-chloro-2-hydroxyphenyl)ethanone

: 1462921-16-9
tert-butyl [2-(6-acetyl-4-chloro-3-cyano-2-iodophenoxy)ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2.1: N-iodo-succinimide; acetic acid / acetic acid; ethyl acetate / 18 h / 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.25 h / Cooling with ice

3.2: 20 °C / Cooling with ice

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; diethylazodicarboxylate; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide;