6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

Base Information

Chemical Name:6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine
CAS No.:139871-38-8
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

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Chemical Property of 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

Chemical Property:

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Technology Process of 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

There total 2 articles about 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 7781-23-9
2,4-dimethoxy-6-methylpyrimidine

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 139871-38-8
6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

Guidance literature:: 2,4-dimethoxy-6-methylpyrimidine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -70 - -55 ℃; for 0.5h; Inert atmosphere;

1,3-dibenzyloxy-2-propanone; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.04.079

Reference yield:

: 6972-79-8
dibenzyl glycerol

: 139871-38-8
6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-chlorosuccinimide, Me₂S, 2.) Et₃N / a.) toluene, -25 deg C, 3 h, b.) r. t., 25 min

2: 1.) n-BuLi / 1.) THF, - 55 deg C, 2.) THF, -55 deg C

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; triethylamine;
DOI:10.1021/jo00038a025