470716-51-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions and transformations, contributing to the development of new drugs.
Used in Agrochemical Production:
2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene also serves as an intermediate in the production of agrochemicals, where its unique properties can be leveraged to create effective and targeted agricultural products.
Used in Dye and Pigment Manufacturing:
2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene is used as a building block in the manufacturing of dyes and pigments, where its specific reactivity and properties contribute to the creation of vibrant and stable colorants.
Used in Specialty Chemicals Industry:
In the specialty chemicals industry, 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene is utilized for its unique properties, making it a valuable component in the production of various specialty chemicals that require specific characteristics for their applications.
Used in Organic Synthesis:
The strong electron-withdrawing properties of the sulfonyl group in 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene make it a useful compound in organic synthesis for a wide range of chemical reactions and transformations.

Upstream product

• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 10213-10-2 sodium tungstate (VI) dihydrate 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 852312-95-9 3-(4-chloro-benzenesulfonyl)-3-(2,5-difluoro-phenyl)-2-methyl-propionic acid methyl ester 
• 471905-61-0 2-[1-[(4-chlorophenyl)sulfonyl]ethenyl]-1,4-difluorobenzene 
• 558463-62-0 3-[2-[(4-Chlorophenyl)sulfonyl]-2-(2,5-difluorophenyl)ethyl]pyridine 
• 558463-59-5 2-[1-[(4-Chlorophenyl)sulfonyl]-2-phenylethyl]-1,4-difluorobenzene 
• 558461-85-1 2-[6-Bromo-1-[(4-chlorophenyl)sulfonyl]hexyl]-1,4-difluorobenzene 
• 558464-45-2 2-[1-(4-Chlorophenylsulfonyl)-3-phenylpropyl]-1,4-difluorobenzene 
• 678982-40-6 (3RS,4RS)-4-(4-chlorobenzenesulfonyl)-4-(2,5-difluorophenyl)-3-methylbutyronitrile 
• 558461-57-7 E-2-[1-[(4-Chlorophenyl)sulfonyl]-2-phenylethenyl]-1,4-difluorobenzene 
• 558461-59-9 2-[(4-Chlorophenyl)sulfonyl]-2-(2,5-difluorophenyl)-1-phenyl-1-ethanone 
• 558461-60-2 2-[(4-chlorophenyl)sulfonyl]-2-(2,5-difluorophenyl)-1-phenylethenyl benzoate 
• 558461-58-8 1-[(4-Chlorophenyl)sulfonyl]-1-(2,5-difluorophenyl)-2-pentanone 
• 558461-61-3 1-[(4-Chlorophenyl)sulfonyl]-1-(2,5-difluorophenyl)-2-pentanol 
• 471903-55-6 4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)tetrahydropyrane 
• 558461-65-7 2-[5-(t-Butyldimethylsilyloxy)-1-[(4-chlorophenyl)sulfonyl]pentyl]-1,4-difluorobenzene 

Relevant academic research and scientific papers

A practical synthesis of a γ-secretase inhibitor

(Chemical Equation Presented) A practical and scaleable synthesis of the γ-secretase inhibitor 1 is reported. The inhibitor consists of a central trisubstituted cyclohexane core with appended propionic acid, 2,5-difluorophenyl, and 4-chlorophenylsulfonyl

CYCLOHEXYL SULPHONES FOR TREATMENT OF CANCER

Sulphones of formula (I) are disclosed for use in treatment of cancer.

HETEROCYCLIC METHYL SULFONE DERIVATIVE

Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents -S-,-SO- or -SO2-) an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

The new cyclohexylpropionic sulfone

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Aryl sulfones: A new class of γ-secretase inhibitors

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS

Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

SYNTHESIS OF CYCLOHEXANONE DERIVATIVES

A novel process for preparing cyclohexanones (1) is described. The products are useful as gamma-secretase inhibitors, or as intermediates in the synthesis of other gamma-secretase inhibitors.

Novel cyclohexyl sulphones

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.