470716-51-9

Basic information

• Product Name: 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene
• Synonyms: 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene;Benzene, 2-[[(4-chlorophenyl)sulfonyl]Methyl]-1,4-difluoro-;2-[(4-chlorobenzenesulfonyl)Methyl]-1,4- difluorobenzene
• CAS NO: 470716-51-9
• Molecular Formula: C₁₃H₉ClF₂O₂S
• Molecular Weight: 302.7241664
• EINECS: 200-589-5
• Mol File: 470716-51-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene(470716-51-9)
• EPA Substance Registry System: 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene(470716-51-9)

Safety Data

• Hazardous Substances Data: 470716-51-9(Hazardous Substances Data)

Usage

General Description

2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene is a chemical compound that consists of a benzene ring with two fluorine atoms at positions 1 and 4, and a sulfonyl-methyl group attached to a 4-chlorophenyl group. 2-((4-chlorophenylsulfonyl)methyl)-1,4-difluorobenzene is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of dyes, pigments, and specialty chemicals. The sulfonyl group is known for its strong electron-withdrawing properties, making this compound useful for various chemical reactions and transformations in organic synthesis. Additionally, the presence of the chlorophenyl and difluorobenzene groups imparts specific reactivity and properties to this compound, making it valuable in a wide range of chemical processes.

Upstream product

• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 106-54-7 p-Chlorothiophenol 
• 10213-10-2 sodium tungstate (VI) dihydrate 

Downstream Products

• 471903-19-2 5-(4-chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 558463-62-0 3-[2-[(4-Chlorophenyl)sulfonyl]-2-(2,5-difluorophenyl)ethyl]pyridine 
• 558463-64-2 2-[3-(4-Chlorophenylsulfonyl)-3-(2,5-difluorophenyl)propyl]thiophene 
• 558461-84-0 2-[[(4-chlorophenyl)sulfonyl](cylcohexyl)methyl]-1,4-difluorobenzene 
• 558464-29-2 4-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)methyl]tetrahydrothiopyrane 
• 558463-46-0 6-[(4-chlorophenyl)sulfonyl]-6-(2,5-difluorophenyl)-1-(1-pyrrolidinyl)-1-hexanone 
• 558463-61-9 2-[2-[(4-Chlorophenyl)sulfonyl]-2-(2,5-difluorophenyl)ethyl]pyridine 
• 678982-40-6 (3RS,4RS)-4-(4-chlorobenzenesulfonyl)-4-(2,5-difluorophenyl)-3-methylbutyronitrile 
• 471903-41-0 trans-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanol 

Relevant articles and documents

A practical synthesis of a γ-secretase inhibitor

(Chemical Equation Presented) A practical and scaleable synthesis of the γ-secretase inhibitor 1 is reported. The inhibitor consists of a central trisubstituted cyclohexane core with appended propionic acid, 2,5-difluorophenyl, and 4-chlorophenylsulfonyl

HETEROCYCLIC METHYL SULFONE DERIVATIVE

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Aryl sulfones: A new class of γ-secretase inhibitors

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.