4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide

Base Information

• Chemical Name: 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide
• CAS No.: 1443762-41-1
• Molecular Formula: C₂₁H₃₂N₄O₄
• Molecular Weight: 404.509
• Mol file: 1443762-41-1.mol

Synonyms:4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide

Chemical Property of 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide

There total 1 articles about 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Aminobutanol (13325-10-5) + 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoic acid (1346263-94-2) → 4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide (1443762-41-1)

Guidance literature:

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;

4-Aminobutanol; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm400520c

Reference yield: 64.0%

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide (1443762-41-1) + 4-ethynyl-N-propylcyclohex-3-enamine (1443762-37-5) → (S)-4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-[4-[(6-ethynylcyclohex-3-enyl)propylamino]butyl]-3-methoxybenzamide

Guidance literature:

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide; With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 1h; Cooling with ice; Inert atmosphere;

4-ethynyl-N-propylcyclohex-3-enamine; With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 4h;

Inert atmosphere;

DOI:10.1021/jm400520c

Reference yield: 63.0%

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide (1443762-41-1) + 4-ethynyl-N-propylcyclohex-3-enamine (1443762-35-3) → (R)-4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-[4-[(6-ethynylcyclohex-3-enyl)propylamino]butyl]-3-methoxybenzamide

Guidance literature:

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-N-(4-hydroxybutyl)-3-methoxybenzamide; With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 1h; Cooling with ice; Inert atmosphere;

4-ethynyl-N-propylcyclohex-3-enamine; With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 4h;

Inert atmosphere;

DOI:10.1021/jm400520c

upstream raw materials:

4-Aminobutanol

4-[3-(1-butyl-1H-1,2,3-triazol-4-yl)propoxy]-3-methoxybenzoic acid