(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

Base Information

Chemical Name:(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester
CAS No.:1294495-52-5
Molecular Formula:C₁₉H₁₅BrO₇
Molecular Weight:435.228
Hs Code.:

Synonyms:(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

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Chemical Property of (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

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Technology Process of (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

There total 9 articles about (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 68204-79-5
2-methoxycarbonyl-4,5-methylenedioxyphenyl acetic acid methyl ester

: 126712-07-0
2-bromo-6-methoxybenzaldehyde

: 1294495-52-5
(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

Guidance literature:: 2-methoxycarbonyl-4,5-methylenedioxyphenyl acetic acid methyl ester; 2-bromo-6-methoxybenzaldehyde; With methanol; sodium methylate; for 4h; Reflux;

With hydrogenchloride; In water; at 0 ℃;
DOI:10.1039/c0ob01214a

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 1294495-52-5
(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: piperidine; pyridine

2.1: 10% palladium on activated charcoal; hydrogen

3.1: oxalyl dichloride / dichloromethane

4.1: tin(IV) chloride

5.1: hydrogenchloride; n-Amyl nitrite / methanol; water

6.1: p-toluenesulfonyl chloride; sodium hydroxide / water

7.1: dichloromethane / 0 °C

8.1: methanol; sodium methylate / 4 h / Reflux

8.2: 0 °C

With piperidine; pyridine; hydrogenchloride; methanol; oxalyl dichloride; n-Amyl nitrite; 10% palladium on activated charcoal; hydrogen; sodium methylate; tin(IV) chloride; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; dichloromethane; water; 4.1: Friedel-Crafts acylation;
DOI:10.1039/c0ob01214a

Reference yield:

: 68996-81-6
3-benzo[1,3]dioxol-5-yl-propionyl chloride

: 1294495-52-5
(Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tin(IV) chloride

2.1: hydrogenchloride; n-Amyl nitrite / methanol; water

3.1: p-toluenesulfonyl chloride; sodium hydroxide / water

4.1: dichloromethane / 0 °C

5.1: methanol; sodium methylate / 4 h / Reflux

5.2: 0 °C

With hydrogenchloride; methanol; n-Amyl nitrite; sodium methylate; tin(IV) chloride; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; dichloromethane; water; 1.1: Friedel-Crafts acylation;
DOI:10.1039/c0ob01214a