126712-07-0

Basic information

• Product Name: 3-Bromo-2-formylanisole
• Synonyms: 3-Bromo-2-formylanisole
• CAS NO: 126712-07-0
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.05
• Mol File: 126712-07-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 41-42 °C
• Boiling Point: 276.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1.522±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerated.
• CAS DataBase Reference: 3-Bromo-2-formylanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-formylanisole(126712-07-0)
• EPA Substance Registry System: 3-Bromo-2-formylanisole(126712-07-0)

Safety Data

• Hazardous Substances Data: 126712-07-0(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-formylanisole is a chemical compound with the molecular formula C8H7BrO2. It is a bromine-substituted derivative of anisole and contains a formyl group. This chemical is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It has a variety of applications in the pharmaceutical and chemical industries, including as a building block in the synthesis of biologically active compounds. 3-Bromo-2-formylanisole is also used in the manufacture of fragrances and flavoring agents. Its unique structure and reactivity make it a valuable compound in organic chemistry and related fields.

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 124-41-4 sodium methylate 
• 1314031-76-9 (E)-2-bromo-6-methoxybenzaldehyde O-methyl oxime 
• 61042-21-5 (E)-2-methoxybenzaldehyde O-methyl oxime 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 107369-63-1 2-methoxybenzaldehyde O-methyloxime 
• 591-20-8 3-Bromophenol 
• 124639-28-7 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine 
• 135-02-4 ortho-anisaldehyde 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 93710-52-2 (2-bromo-6-methoxyphenyl)methanol 
• 1294495-52-5 (Z/E)-3-(2-bromo-6-methoxyphenyl)-2-(2-carboxy-4,5-methylenedioxyphenyl)acrylic acid methyl ester 
• 946614-48-8 methyl 2-(2-(cyanomethyl)-6-methoxy-4-methylphenyl)acetonitrile 
• 830-54-6 8-methoxy-3-methyl-1H-isochromen-1-one 
• 75115-29-6 2-Methoxy-6-(2-oxo-propyl)-benzoic acid 

Relevant articles and documents

Atroposelective Synthesis of Axially Chiral 4-Aryl α-Carbolines via N-Heterocyclic Carbene Catalysis

The first catalytic asymmetric construction of axially chiral 4-aryl α-carboline skeletons has been accomplished through an N-heterocyclic carbene (NHC)-catalyzed atroposelective formal [3 + 3] annulation of 4-nitrophenyl 3-arylpropiolates with 2-sulfonamidoindolines. The synthetic utility of the title compounds has been demonstrated by the diverse late-stage structural modifications. Density functional theory calculations were also conducted to illuminate the key factors for controlling the origin of the enantioselectivity. This strategy not only provides an efficient pathway to access axially chiral α-carboline atropisomers but also offers a novel catalytic enantioselective mode for the construction of axially chiral heterobiaryls by using NHC-bound alkynyl acylazoliums.

Dihydroisocoumarin derivative and preparation method and application thereof

The present invention discloses a dihydroisocoumarin derivative and preparation method and application thereof, the dihydroisocoumarin derivative having a structure as shown in formula (I) or (II). The method of preparing dihydroisocoumarin derivatives of

TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X11 and X22 are independently C or N, provided that zero or one of X11 and X22 is N; Ring A represented by the structure is: or; and Q, R11, R22, R33, R44, R66, and p are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.