3-Bromo-2-formylanisole

Base Information

• Chemical Name: 3-Bromo-2-formylanisole
• CAS No.: 126712-07-0
• Molecular Formula: C8H7 Br O2
• Molecular Weight: 215.046
• Hs Code.: 2913000090
• Mol file: 126712-07-0.mol

Synonyms:3-Bromo-2-formylanisole

Chemical Property of 3-Bromo-2-formylanisole

Chemical Property:

• Melting Point: 41-42 °C
• Boiling Point: 276.0±20.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.522±0.06 g/cm3(Predicted)
• LogP: 2.27020
• Storage Temp.: Refrigerated.

Purity/Quality:

99.3% ^*data from raw suppliers

2-Bromo-6-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-formylanisole

There total 17 articles about 3-Bromo-2-formylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-6-hydroxybenzaldehyde (22532-61-2) + methyl iodide (74-88-4) → 2-bromo-6-methoxybenzaldehyde (126712-07-0)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 12h;

Reference yield: 95.0%

2-bromo-6-methoxybenzaldehyde O-methyloxime → 2-bromo-6-methoxybenzaldehyde (126712-07-0)

Guidance literature:

With formaldehyd; toluene-4-sulfonic acid; In tetrahydrofuran; water; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jo200853j

Reference yield: 89.0%

(E)-2-bromo-6-methoxybenzaldehyde O-methyl oxime (1314031-76-9) → 2-bromo-6-methoxybenzaldehyde (126712-07-0)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; at 100 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

2-bromo-6-hydroxybenzaldehyde

methyl iodide

ortho-anisaldehyde

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine

Downstream raw materials:

2-bromo-6-methoxybenzoic acid

2-(benzyloxy)-6-bromobenzaldehyde

5-bromo-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran

Refernces

• 1、 -. "ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF". . . Retrieved 2021/06/22.
• 2、 -. "Dihydroisocoumarin derivative and preparation method and application thereof". Paragraph 0043; 0045; 0049-0050. . Retrieved 2022/01/10.