(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Base Information

Chemical Name:(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol
CAS No.:1332640-34-2
Molecular Formula:C₂₃H₃₉NO₄Si
Molecular Weight:421.652
Hs Code.:

Synonyms:(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Suppliers and Price of (R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

There total 4 articles about (R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 593-60-2,25951-54-6
Vinyl bromide

: 1233851-77-8
C₂₁H₃₅NO₄Si

: 1332640-34-2
(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: Vinyl bromide; With magnesium; In tetrahydrofuran;

C₂₁H₃₅NO₄Si; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.07.032

Reference yield: 72.0%

: 1233851-77-8
C₂₁H₃₅NO₄Si

: 1826-67-1
vinyl magnesium bromide

: 1332640-34-2
(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; for 2h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201201342

Reference yield:

: 217309-46-1
5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose

: 1332640-34-2
(R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / Reflux

2.1: magnesium / tetrahydrofuran

2.2: 2 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

With magnesium; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2011.07.032