4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester

Base Information

• Chemical Name: 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester
• CAS No.: 20483-30-1
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.268
• Mol file: 20483-30-1.mol

Synonyms:4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester

Chemical Property of 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester

There total 4 articles about 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-(2-hydroxy-5-methylphenyl)-4-oxobutanoic acid (103987-17-3) + dimethyl sulfate (77-78-1) → 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester (20483-30-1)

Guidance literature:

With potassium carbonate; In acetone; Heating;

Reference yield:

methanol (67-56-1) + methyl 4-(2-hydroxymethyl-5-ethylphenyl)-4-carbonylbutanoate (55007-22-2) → 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester (20483-30-1)

Guidance literature:

With sulfuric acid; at 20 ℃; for 5h; Large scale;

Reference yield:

p-methylanizole (104-93-8) → 4-(2-methoxy-5-methyl-phenyl)-4-oxo-butyric acid methyl ester (20483-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / -5 - 10 °C / Large scale

2: sulfuric acid / 5 h / 20 °C / Large scale

With aluminum (III) chloride; sulfuric acid; In dichloromethane;

upstream raw materials:

methyl 4-(2-hydroxymethyl-5-ethylphenyl)-4-carbonylbutanoate

4-(2-hydroxy-5-methylphenyl)-4-oxobutanoic acid

dimethyl sulfate

p-methylanizole

Downstream raw materials:

2-(2-methoxy-5-methyl-phenyl)-2,5,5-tris-(2-methoxy-phenyl)-tetrahydro-furan

4-(2-methoxy-5-methyl-phenyl)-4-(2-methoxy-phenyl)-but-3ξ-enoic acid