5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

Base Information

Chemical Name:5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone
CAS No.:1219095-74-5
Molecular Formula:C₂₂H₁₃F₄NO₄
Molecular Weight:431.343
Hs Code.:

Synonyms:5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

Chemical Property:

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Technology Process of 5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

There total 5 articles about 5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219095-73-4
5-(2-fluorophenyl)-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

: 1219095-74-5
5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

Guidance literature:: With Darco G-60; In ethyl acetate;

Reference yield:

: 850991-69-4
5-methoxy-3-pyridinylboronic acid

: 1219095-74-5
5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

2: Darco_.(R). G-60 / ethyl acetate

With benzyltrimethylammonium chloride; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; ethyl acetate; toluene;

Reference yield:

: 918418-99-2
ethyl 2,4,6-trifluorophenylglyoxylate

: 1219095-74-5
5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: isopropylmagnesium chloride / diethyl ether / -78 - 5 °C

2.2: 0.33 h

3.1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

4.1: Darco_.(R). G-60 / ethyl acetate

With isopropylmagnesium chloride; benzyltrimethylammonium chloride; triphenylphosphine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; dichloromethane; water; ethyl acetate; toluene;