1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Base Information

Chemical Name:1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS No.:25673-61-4
Molecular Formula:C₂₁H₁₈N₂O₅
Molecular Weight:378.384
Hs Code.:

Synonyms:1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

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Chemical Property of 1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

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Technology Process of 1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

There total 6 articles about 1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.4%

: 34231-78-2
3-formylphenyl acetate

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 25673-60-3
trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

: 25673-61-4
1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: With sodium acetate; acetic anhydride; at 150 ℃; for 3h;
DOI:10.1021/jo00133a042

Reference yield: 10.0%

: 34231-78-2
3-formylphenyl acetate

: 108-24-7
acetic anhydride

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 25673-60-3
trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

: 25673-61-4
1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: With sodium acetate; at 150 ℃; for 3h;
DOI:10.1021/jo00133a042

Reference yield:

: 81245-94-5
2-bromo-N-(methoxymethyl)-N-(N-methylglycyl)aniline

: 25673-61-4
1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / triphenyl phosphine, tri-n-butylamine / palladium acetate / hexamethylphosphoric acid triamide / 48 h / 120 °C / 3800 Torr

2: 84.6 percent / 10percent aq. hydrochloric acid / methanol / 3 h / 50 °C

3: 24.4 percent / sodium acetate / 3 h / 150 °C

With hydrogenchloride; tributyl-amine; sodium acetate; triphenylphosphine; palladium diacetate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00133a042