trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Base Information

Chemical Name:trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS No.:25673-60-3
Molecular Formula:C₁₉H₁₆N₂O₄
Molecular Weight:336.347
Hs Code.:

Synonyms:trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

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Chemical Property of trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

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Technology Process of trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

There total 9 articles about trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.4%

: 34231-78-2
3-formylphenyl acetate

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 25673-60-3
trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

: 25673-61-4
1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: With sodium acetate; acetic anhydride; at 150 ℃; for 3h;
DOI:10.1021/jo00133a042

Reference yield: 10.0%

: 34231-78-2
3-formylphenyl acetate

: 108-24-7
acetic anhydride

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 25673-60-3
trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

: 25673-61-4
1-acetyl-trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: With sodium acetate; at 150 ℃; for 3h;
DOI:10.1021/jo00133a042

Reference yield:

: 81255-43-8
2-bromo-N-aniline

: 25673-60-3
trans-3-(3-acetoxybenzylidene)-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hydride / 1.) THF, 0 deg C, 1.5 h, 2a.) 0 deg C, 30 min, 2b.) room temp., 3 h

2: 93 percent / aq. potassium carbonate / methanol / 3 h / Ambient temperature

3: 41 percent / triphenyl phosphine, tri-n-butylamine / palladium acetate / hexamethylphosphoric acid triamide / 48 h / 120 °C / 3800 Torr

4: 84.6 percent / 10percent aq. hydrochloric acid / methanol / 3 h / 50 °C

5: 10 percent / sodium acetate / 3 h / 150 °C

With hydrogenchloride; tributyl-amine; sodium acetate; sodium hydride; potassium carbonate; triphenylphosphine; palladium diacetate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00133a042