cyclo

Base Information

Chemical Name:cyclo
CAS No.:104849-14-1
Molecular Formula:C₂₆H₃₅ClN₄O₅
Molecular Weight:519.041
Hs Code.:

cyclo<L-2-amino-8-oxo-9-chlorononanoyl-D-prolyl-L-phenylalanyl-D-alanyl>

Synonyms:cyclo

Suppliers and Price of cyclo

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclo

Chemical Property:

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Technology Process of cyclo

There total 7 articles about cyclo which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104849-08-3
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

: 104849-14-1
cyclo

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / 1.0 N aq. NaOH / methanol / Ambient temperature

2: 83 percent / H₂ / 10percent Pd/C / methanol / 3 h

3: 11 percent / Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 64 h / -10 - 20 °C

4: TFA / CH₂Cl₂ / 1 h / Ambient temperature

5: N-methylmorpholine / tetrahydrofuran / 1 h / 0 - 20 °C

6: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

7: HCl gas / diethyl ether; tetrahydrofuran / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00384a013

Reference yield:

: 104849-09-4
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

: 104849-14-1
cyclo

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / H₂ / 10percent Pd/C / methanol / 3 h

2: 11 percent / Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 64 h / -10 - 20 °C

3: TFA / CH₂Cl₂ / 1 h / Ambient temperature

4: N-methylmorpholine / tetrahydrofuran / 1 h / 0 - 20 °C

5: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

6: HCl gas / diethyl ether; tetrahydrofuran / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00384a013

Reference yield:

: 104849-13-0
(5S,8R,11S,13aR)-11-Benzyl-5-(7-diazo-6-oxo-heptyl)-8-methyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

: 104849-14-1
cyclo

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; diethyl ether; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00384a013