N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

Base Information

Chemical Name:N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride
CAS No.:96705-74-7
Molecular Formula:C₂₂H₂₆NO₄*Cl
Molecular Weight:403.906
Hs Code.:

Synonyms:N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

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Chemical Property of N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

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Technology Process of N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

There total 7 articles about N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.7%

: 96705-73-6
trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 96705-74-7
N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

Guidance literature:: palladium on activated charcoal; In acetic acid; for 29h; Heating;
DOI:10.1021/jm00146a010

Reference yield:

: 5653-42-9
3,4-dimethoxyhomophthalic anhydride

: 96705-74-7
N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / CHCl₃ / 0.5 h / Ambient temperature

2: 49 percent / cupric acetate / benzene; pyridine / a) 3 h, b) 80 deg C, 3 h

3: 62 percent / LAH / tetrahydrofuran / 27 h / Heating

4: 61.7 percent / 5percent Pd/C / acetic acid / 29 h / Heating

With lithium aluminium tetrahydride; copper diacetate; palladium on activated charcoal; In tetrahydrofuran; pyridine; chloroform; acetic acid; benzene;
DOI:10.1021/jm00146a010

Reference yield:

: 2538-98-9
4-isopropyloxy-3-methoxybenzaldehyde

: 96705-74-7
N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-6,7-dimethoxyisoquinolinium chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / ethanol; H₂O / 6 h / Ambient temperature

2: 35 percent / CHCl₃ / 0.5 h / Ambient temperature

3: 49 percent / cupric acetate / benzene; pyridine / a) 3 h, b) 80 deg C, 3 h

4: 62 percent / LAH / tetrahydrofuran / 27 h / Heating

5: 61.7 percent / 5percent Pd/C / acetic acid / 29 h / Heating

With lithium aluminium tetrahydride; copper diacetate; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; chloroform; water; acetic acid; benzene;
DOI:10.1021/jm00146a010