trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:96705-73-6
Molecular Formula:C₂₂H₂₉NO₅
Molecular Weight:387.476
Hs Code.:

Synonyms:trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 96705-71-4
trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-acetoxy-6,7-dimethoxy-3,4-dihydro-1(2H)-isoquinolone

: 96705-73-6
trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 27h; Heating;
DOI:10.1021/jm00146a010

Reference yield:

: 5653-42-9
3,4-dimethoxyhomophthalic anhydride

: 96705-73-6
trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / CHCl₃ / 0.5 h / Ambient temperature

2: 49 percent / cupric acetate / benzene; pyridine / a) 3 h, b) 80 deg C, 3 h

3: 62 percent / LAH / tetrahydrofuran / 27 h / Heating

With lithium aluminium tetrahydride; copper diacetate; In tetrahydrofuran; pyridine; chloroform; benzene;
DOI:10.1021/jm00146a010

Reference yield:

: 2538-98-9
4-isopropyloxy-3-methoxybenzaldehyde

: 96705-73-6
trans-N-methyl-3-(4-isopropoxy-3-methoxyphenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / ethanol; H₂O / 6 h / Ambient temperature

2: 35 percent / CHCl₃ / 0.5 h / Ambient temperature

3: 49 percent / cupric acetate / benzene; pyridine / a) 3 h, b) 80 deg C, 3 h

4: 62 percent / LAH / tetrahydrofuran / 27 h / Heating

With lithium aluminium tetrahydride; copper diacetate; In tetrahydrofuran; pyridine; ethanol; chloroform; water; benzene;
DOI:10.1021/jm00146a010