5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole
• CAS No.: 519002-88-1
• Molecular Formula: C₁₆H₂₆N₄O₃SSi
• Molecular Weight: 382.559
• Mol file: 519002-88-1.mol

Synonyms:5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole

Chemical Property of 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 6 articles about 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-[3-(tert-butyl-dimethyl-silanyloxy)-propylsulfanyl]-1-phenyl-1H-tetrazole → 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole (519002-88-1)

Guidance literature:

With dihydrogen peroxide; In ethanol; at 0 ℃; for 10h;

DOI:10.1002/cbic.201200315

Reference yield:

3-tert-butyldimethylsilyloxy-1-propanol (73842-99-6) → 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole (519002-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Ph₃P; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

1.2: 89 percent / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: 69 percent / m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 1.5 h / 20 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction;

DOI:10.1021/ja021327y

Reference yield:

1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole (519002-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Ph₃P; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

1.2: 89 percent / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: 69 percent / m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 1.5 h / 20 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction;

DOI:10.1021/ja021327y

upstream raw materials:

3-tert-butyldimethylsilyloxy-1-propanol

1-Phenyl-1H-tetrazole-5-thiol

3-(tert-butyldimethylsilyloxy)propyl bromide

tert-butyldimethylsilyl chloride