9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Base Information

Chemical Name:9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
CAS No.:172326-40-8
Molecular Formula:C₂₄H₂₄N₄O₄
Molecular Weight:432.479
Hs Code.:

Synonyms:9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

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Chemical Property of 9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

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Technology Process of 9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

There total 9 articles about 9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 122439-11-6
tributyl(3-methoxyphenyl)stannane

: 1026543-86-1
Trifluoro-methanesulfonic acid 9-[1,3]dioxan-2-yl-5-ethyl-11-oxo-10,11-dihydro-5H-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-7-yl ester

: 172326-40-8
9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In N,N-dimethyl-formamide; at 110 ℃;
DOI:10.1021/jm00024a011

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 172326-40-8
9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / i-PrNEt₂ / ethyl acetate / 0 °C

2: 77 percent / 110 °C

3: 66 percent / NaHMDS, pyridine / 90 °C

4: 79 percent / LiI, 2,6-collidine / 160 °C

5: 73 percent / diisopropylethylamine / CH₂Cl₂ / 0.25 h / 0 °C

6: 100 percent / PdCl₂(Ph₃P)2, LiCl / dimethylformamide / 110 °C

With pyridine; 2,4,6-trimethyl-pyridine; bis-triphenylphosphine-palladium(II) chloride; N,N-diethyl-N-isopropylamine; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium iodide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00024a011

Reference yield:

: 162709-28-6
2,6-Dimethoxy-4-formyl-3-pyridinecarbamic acid 1,1-dimethylethyl ester

: 172326-40-8
9-[1,3]Dioxan-2-yl-5-ethyl-7-(3-methoxy-phenyl)-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / Amberlyst 15 / tetrahydrofuran / Ambient temperature

2: 95 percent / HCl / ethyl acetate

3: 86 percent / i-PrNEt₂ / ethyl acetate / 0 °C

4: 77 percent / 110 °C

5: 66 percent / NaHMDS, pyridine / 90 °C

6: 79 percent / LiI, 2,6-collidine / 160 °C

7: 73 percent / diisopropylethylamine / CH₂Cl₂ / 0.25 h / 0 °C

8: 100 percent / PdCl₂(Ph₃P)2, LiCl / dimethylformamide / 110 °C

With pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; Amberlyst 15; N,N-diethyl-N-isopropylamine; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium iodide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00024a011