2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

Base Information

Chemical Name:2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one
CAS No.:1044872-54-9
Molecular Formula:C₂₀H₂₂N₂O₆
Molecular Weight:386.404
Hs Code.:

Synonyms:2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

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Chemical Property of 2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

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Technology Process of 2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

There total 8 articles about 2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.7%

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 676597-00-5
3-(2-hydroxy-ethyl)-4-methoxymethoxy-benzaldehyde

: 1044872-54-9
2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 20 - 150 ℃;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1044872-54-9
2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / [⁽²⁾H₆]acetone / 2.5 h / 0 - 70 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

3.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 20 °C

4.1: manganese(IV) oxide / chloroform / 3 h / 80 °C / Inert atmosphere

5.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In tetrahydrofuran; [⁽²⁾H₆]acetone; chloroform; N,N-dimethyl acetamide; toluene;

Reference yield:

: 162269-90-1
3-bromo-4-(methoxymethoxy)benzaldehyde

: 1044872-54-9
2-[3-(2-hydroxy-ethyl)-4-methoxymethoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C

3.1: manganese(IV) oxide / chloroform / 3 h / 80 °C / Inert atmosphere

4.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; toluene-4-sulfonic acid; sodium hydrogensulfite; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide; toluene;