γ-methyl-γ-p-tolyl-vinylacetic acid

Base Information

• Chemical Name: γ-methyl-γ-p-tolyl-vinylacetic acid
• CAS No.: 16020-19-2
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• Mol file: 16020-19-2.mol

Synonyms:γ-methyl-γ-p-tolyl-vinylacetic acid

Chemical Property of γ-methyl-γ-p-tolyl-vinylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of γ-methyl-γ-p-tolyl-vinylacetic acid

There total 5 articles about γ-methyl-γ-p-tolyl-vinylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2(p-tolyl) 1-methoxy 1-propene (66334-30-3) → γ-methyl-γ-p-tolyl-vinylacetic acid (16020-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / acetone; water / 0 - 20 °C

2: triethylamine / Reflux

With hydrogen bromide; triethylamine; In water; acetone;

DOI:10.1021/jacs.8b01886

Reference yield:

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) → γ-methyl-γ-p-tolyl-vinylacetic acid (16020-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / diethyl ether / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydrogen bromide / acetone; water / 0 - 20 °C

3.1: triethylamine / Reflux

With potassium tert-butylate; hydrogen bromide; triethylamine; In diethyl ether; water; acetone;

DOI:10.1021/jacs.8b01886

Reference yield:

malonic acid (141-82-2) + 2-(4-methylphenyl)propanal (33596-66-6,122091-53-6,122091-55-8,99-72-9) → γ-methyl-γ-p-tolyl-vinylacetic acid (16020-19-2)

Guidance literature:

With triethylamine; Reflux;

DOI:10.1021/jacs.8b01886

upstream raw materials:

methyl magnesium iodide

ethyl 4-oxo-4-(p-tolyl)butanoate

diethyl ether

methylmagnesium bromide

Downstream raw materials:

4-p-tolylpentanoic acid

(±)-5-(4-methylphenyl)-γ-valerolactone

4-p-tolyl-valeric acid ethyl ester

(E)-methyl 4-(p-tolyl)pent-3-enoate