methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate

Base Information

• Chemical Name: methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate
• CAS No.: 666705-60-8
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 282.301
• Mol file: 666705-60-8.mol

Synonyms:methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate

Chemical Property of methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate

There total 2 articles about methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-propane (75-30-9) + methyl 3-(4-methoxyphenyl)-2-nitroacrylate (116471-68-2) → methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate (666705-60-8)

Guidance literature:

With triethyl borane; tributyltin deuteride; zinc(II) chloride; oxygen; In diethyl ether; hexane; dichloromethane; at -78 ℃; for 3h;

DOI:10.1021/ol036461h

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate (666705-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄; N-methylmorpholine / tetrahydrofuran; CH₂Cl₂ / -10 - 20 °C

2: ZnCl₂; Bu₃SnD; Et₃B / O₂ / CH₂Cl₂; diethyl ether; hexane / 3 h / -78 °C

With 4-methyl-morpholine; triethyl borane; titanium tetrachloride; tributyltin deuteride; zinc(II) chloride; oxygen; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1: Knoevenagel condensation;

DOI:10.1021/jo051334f

Reference yield:

methyl 2-deuterio-3-(4-methoxyphenyl)-4-methyl-2-nitropentanoate (666705-60-8) → C14H20(2)HNO3

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h; under 760 Torr;

DOI:10.1021/ol036461h

upstream raw materials:

2-iodo-propane

methyl 3-(4-methoxyphenyl)-2-nitroacrylate

4-methoxy-benzaldehyde