2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

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Chemical Name:2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide
CAS No.:1312940-70-7
Molecular Formula:C₂₅H₁₇F₂N₅O₄S
Molecular Weight:521.504
Hs Code.:

Synonyms:2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

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Chemical Property of 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

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Technology Process of 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

There total 6 articles about 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052686-60-8
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

: 1312942-01-0
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

: 1312940-70-7
2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetonitrile; at 160 ℃; for 0.25h; microwave irradiation;

Reference yield:

: 96516-29-9
2-fluoro-3-nitrobenzaldehyde

: 1312940-70-7
2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: water; aminosulfonic acid; sodium chlorite / 1,4-dioxane / 0.5 h / 20 °C

2: thionyl chloride / N,N-dimethyl-formamide / 80 °C

3: aluminum (III) chloride / nitromethane / 6 h / 45 °C

4: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

5: pyridine / tetrahydrofuran / 48 h / 20 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 0.25 h / 160 °C / microwave irradiation

With pyridine; aluminum (III) chloride; sodium chlorite; thionyl chloride; tin(II) chloride dihdyrate; aminosulfonic acid; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; nitromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1214341-16-8
2-fluoro-3-nitro-benzoyl chloride

: 1312940-70-7
2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / nitromethane / 6 h / 45 °C

2: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

3: pyridine / tetrahydrofuran / 48 h / 20 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 0.25 h / 160 °C / microwave irradiation

With pyridine; aluminum (III) chloride; tin(II) chloride dihdyrate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; nitromethane; water; ethyl acetate; acetonitrile;