N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

Base Information

Chemical Name:N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide
CAS No.:1312942-01-0
Molecular Formula:C₂₀H₁₂BrF₂N₃O₃S
Molecular Weight:492.3
Hs Code.:

Synonyms:N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

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Chemical Property of N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

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Technology Process of N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

There total 5 articles about N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254567-33-3
(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1312942-01-0
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 96516-29-9
2-fluoro-3-nitrobenzaldehyde

: 1312942-01-0
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: water; aminosulfonic acid; sodium chlorite / 1,4-dioxane / 0.5 h / 20 °C

2: thionyl chloride / N,N-dimethyl-formamide / 80 °C

3: aluminum (III) chloride / nitromethane / 6 h / 45 °C

4: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

5: pyridine / tetrahydrofuran / 48 h / 20 °C

With pyridine; aluminum (III) chloride; sodium chlorite; thionyl chloride; tin(II) chloride dihdyrate; aminosulfonic acid; water; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; nitromethane; ethyl acetate;

Reference yield:

: 317-46-4
2-fluoro-3-nitro-benzoic acid

: 1312942-01-0
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / 80 °C

2: aluminum (III) chloride / nitromethane / 6 h / 45 °C

3: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

4: pyridine / tetrahydrofuran / 48 h / 20 °C

With pyridine; aluminum (III) chloride; thionyl chloride; tin(II) chloride dihdyrate; N,N-dimethyl-formamide; In tetrahydrofuran; nitromethane; ethyl acetate;