6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:1421253-35-1
Molecular Formula:C₃₄H₃₆N₄O₃S
Molecular Weight:580.751
Hs Code.:

Synonyms:6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Chemical Property of 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 9 articles about 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

: 1421253-34-0
4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-35-1
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: With palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; at 120 ℃; for 1.5h; Microwave irradiation; Inert atmosphere; Sealed tube;

Reference yield:

: 499-75-2
carvacrol

: 1421253-35-1
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With pyridine; palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1421067-10-8
6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-35-1
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water; tetrahydrofuran / 1.5 h

3: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; palladium diacetate; sodium carbonate; caesium carbonate; acetic acid; XPhos; In tetrahydrofuran; 1,2-dimethoxyethane; water;