(S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

• Chemical Name: (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• CAS No.: 1421249-12-8
• Molecular Formula: C₃₄H₄₃N₅O
• Molecular Weight: 537.748
• Mol file: 1421249-12-8.mol

Synonyms:(S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Chemical Property of (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 13 articles about (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (1421253-37-3) → (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (1421249-12-8)

Guidance literature:

With ammonium hydroxide; potassium hydroxide; In methanol; water; at 80 ℃; for 1.25h; Microwave irradiation;

Reference yield:

5-isopropyl-2-methylphenyl trifluoromethanesulfonate (63028-16-0) → (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (1421249-12-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

2.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

2.2: 0.42 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3.5 h / 125 °C / Sealed tube; Microwave irradiation

4.1: ammonium hydroxide; potassium hydroxide / methanol; water / 1.25 h / 80 °C / Microwave irradiation

With hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; XPhos; In tetrahydrofuran; methanol; ethanol; water; isopropyl alcohol;

Reference yield:

carvacrol (499-75-2) → (S)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (1421249-12-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

3.2: 0.42 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3.5 h / 125 °C / Sealed tube; Microwave irradiation

5.1: ammonium hydroxide; potassium hydroxide / methanol; water / 1.25 h / 80 °C / Microwave irradiation

With pyridine; hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; XPhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

5-isopropyl-2-methylphenyl trifluoromethanesulfonate

carvacrol

6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine