4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

Base Information

Chemical Name:4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester
CAS No.:1203662-69-4
Molecular Formula:C₂₃H₂₅BrFN₃O₄
Molecular Weight:506.372
Hs Code.:

Synonyms:4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

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Chemical Property of 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

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Technology Process of 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

There total 6 articles about 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1203662-67-2
4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

: 1203662-69-4
4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at -15 ℃;

Reference yield:

: 1203662-35-4
2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

: 1203662-69-4
4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / 1,2-dimethoxyethane / 1.5 h / 90 °C

2: triethylamine / dichloromethane / 18 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / Inert atmosphere; Heating

4: N-Bromosuccinimide / dichloromethane / 1.25 h / -15 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; hydrazine hydrate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm2017094

Reference yield:

: 1203662-37-6
4-bromo-1H-indazole-5-carboxylic acid tert-butyl ester

: 1203662-69-4
4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / Inert atmosphere; Heating

3: N-Bromosuccinimide / dichloromethane / 1.25 h / -15 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;
DOI:10.1021/jm2017094