4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester
CAS No.:1203662-67-2
Molecular Formula:C₂₆H₃₄FN₃O₄Si
Molecular Weight:499.658
Hs Code.:

Synonyms:4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

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Technology Process of 4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

There total 5 articles about 4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 955372-99-3
2-fluoro-4-trimethylsilanylphenylamine

: 1203662-32-1
4-bromo-indazole-1,5-dicarboxylic acid di-tert-butyl ester

: 1203662-67-2
4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With phosphate potassium salt; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1203662-35-4
2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

: 1203662-67-2
4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 1,2-dimethoxyethane / 1.5 h / 90 °C

2: triethylamine / dichloromethane / 18 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / Inert atmosphere; Heating

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrazine hydrate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm2017094

Reference yield:

: 951884-50-7
2-bromo-4-fluorobenzoic acid tert-butyl ester

: 1203662-67-2
4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -75 °C

1.2: 0.17 h

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 1.5 h / 90 °C

3.1: triethylamine / dichloromethane / 18 h / 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 4 h / Inert atmosphere; Heating

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrazine hydrate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm2017094