1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene

Base Information

• Chemical Name: 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene
• CAS No.: 161036-62-0
• Molecular Formula: C₁₃H₂₁ClOSi
• Molecular Weight: 256.848
• Mol file: 161036-62-0.mol

Synonyms:1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene

Chemical Property of 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene

There total 1 articles about 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

chloro-trimethyl-silane (75-77-4) + 3-chloro-6-methyl-2-(2-propenyl)-2-cyclohexenone (143675-85-8) → 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene (161036-62-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

DOI:10.1021/jo00108a017

Reference yield:

1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene (161036-62-0) → 3-Chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalic acid

Guidance literature:

Multi-step reaction with 3 steps

1: xylene / 1.) 70 deg C, 2 h, 2.) 145 deg C, 4 h

2: 89 percent / K₂CO₃ / dimethylformamide / 2.5 h / 25 °C

3: aq. LiOH / methanol / 5 h / 80 °C

With lithium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide; xylene;

DOI:10.1021/jo00108a017

Reference yield:

1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene (161036-62-0) → Dimethyl 3-chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalate (161036-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene / 1.) 70 deg C, 2 h, 2.) 145 deg C, 4 h

2: 89 percent / K₂CO₃ / dimethylformamide / 2.5 h / 25 °C

With potassium carbonate; In N,N-dimethyl-formamide; xylene;

DOI:10.1021/jo00108a017

upstream raw materials:

chloro-trimethyl-silane

3-chloro-6-methyl-2-(2-propenyl)-2-cyclohexenone

Downstream raw materials:

Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate

Dimethyl 3-chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalate