Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate

Base Information

• Chemical Name: Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate
• CAS No.: 161036-65-3
• Molecular Formula: C₁₄H₁₅ClO₅
• Molecular Weight: 298.723
• Mol file: 161036-65-3.mol

Synonyms:Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate

Chemical Property of Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate

There total 1 articles about Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) + 1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene (161036-62-0) → Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate (161036-65-3)

Guidance literature:

In xylene; Yield given; 1.) 70 deg C, 2 h, 2.) 145 deg C, 4 h;

DOI:10.1021/jo00108a017

Reference yield: 89.0%

Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate (161036-65-3) + methyl iodide (74-88-4) → Dimethyl 3-chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalate (161036-66-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2.5h;

DOI:10.1021/jo00108a017

Reference yield:

Dimethyl 3-chloro-5-hydroxy-6-methyl-4-(2-propenyl)phthalate (161036-65-3) → 3-Chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 2.5 h / 25 °C

2: aq. LiOH / methanol / 5 h / 80 °C

With lithium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00108a017

upstream raw materials:

dimethyl acetylenedicarboxylate

1-Chloro-4-methyl-2-(2-propenyl)-3-((trimethylsilyl)oxy)-1,3-cyclohexadiene

Downstream raw materials:

Dimethyl 3-chloro-5-methoxy-6-methyl-4-(2-propenyl)phthalate