N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

Base Information

Chemical Name:N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine
CAS No.:913078-79-2
Molecular Formula:C₂₄H₂₆F₃N₃O₅S
Molecular Weight:525.549
Hs Code.:

Synonyms:N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

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Chemical Property of N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

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Technology Process of N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

There total 11 articles about N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 913078-53-2
5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

: 913078-79-2
N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; at 78 ℃; for 2.5h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-79-2
N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 74 percent / potassium carbonate / dimethylformamide / 0.67 h / 65 °C

6: 100 percent / hydroxylamine hydrochloride; triethylamine / ethanol / 2.5 h / 78 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-79-2
N'-hydroxy-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamidine

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 74 percent / potassium carbonate / dimethylformamide / 0.67 h / 65 °C

6: 100 percent / hydroxylamine hydrochloride; triethylamine / ethanol / 2.5 h / 78 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067