5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

Base Information

Chemical Name:5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide
CAS No.:913078-53-2
Molecular Formula:C₂₄H₂₃F₃N₂O₄S
Molecular Weight:492.519
Hs Code.:

Synonyms:5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

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Technology Process of 5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

There total 9 articles about 5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

: 17201-43-3
4-cyanobenzyl bromide

: 913078-53-2
5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-53-2
5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 74 percent / potassium carbonate / dimethylformamide / 0.67 h / 65 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-53-2
5-methyl-furan-2-sulfonic acid [2-(4-cyano-benzyloxy)-4-trifluoromethyl-phenyl]-isobutyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 74 percent / potassium carbonate / dimethylformamide / 0.67 h / 65 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067