ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

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Chemical Name:ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate
CAS No.:1233540-80-1
Molecular Formula:C₂₂H₂₇N₃O₇S
Molecular Weight:477.538
Hs Code.:

Synonyms:ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

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Chemical Property of ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

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Technology Process of ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

There total 6 articles about ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 1233540-79-8
4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

: 1233540-80-1
ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: 4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at -10 - 10 ℃;

2-acetylpropanoic acid ethyl ester; With potassium hydroxide; In ethanol; water; acetonitrile; at -40 - -28 ℃;

Reference yield:

: 343262-51-1
2-bromo-5-methanesulfonylpyridine

: 1233540-80-1
ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

2.1: water; calcium chloride; iron / ethanol / 4 h / 80 °C

3.1: hydrogenchloride; sodium nitrite / acetonitrile; water / -10 - 10 °C

3.2: -40 - -28 °C

With hydrogenchloride; water; iron; caesium carbonate; calcium chloride; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1233540-80-1
ethyl (2E)-2-{[4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 1 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

2.2: 4 h / 120 °C

2.3: 2 h / 10 - 35 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

4.1: water; calcium chloride; iron / ethanol / 4 h / 80 °C

5.1: hydrogenchloride; sodium nitrite / acetonitrile; water / -10 - 10 °C

5.2: -40 - -28 °C

With hydrogenchloride; water; iron; sodium hydride; caesium carbonate; calcium chloride; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;