[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester

Base Information

• Chemical Name: [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester
• CAS No.: 271244-00-9
• Molecular Formula: C₁₇H₂₄O₆
• Molecular Weight: 324.374

Synonyms:[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester

Chemical Property of [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester

There total 3 articles about [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester (271244-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; DMS / tetrahydrofuran

2: NaH / 1,2-dimethoxy-ethane

With copper(l) iodide; 2,3-dimercapto-succinic acid; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Grignard reaction / 2: Substitution;

DOI:10.1016/S0040-4039(00)00031-9

Reference yield:

2,3-isopropylidene-glyceraldehyde (15186-48-8) → [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester (271244-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; DMS / tetrahydrofuran

2: NaH / 1,2-dimethoxy-ethane

With copper(l) iodide; 2,3-dimercapto-succinic acid; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Grignard reaction / 2: Substitution;

DOI:10.1016/S0040-4039(00)00031-9

Reference yield:

ethyl bromoacetate (105-36-2) + (2R,3R)-3-hydroxy-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol (102389-96-8) → [(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-acetic acid ethyl ester (271244-00-9)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane;

DOI:10.1016/S0040-4039(00)00031-9

upstream raw materials:

ethyl bromoacetate

(2R,3R)-3-hydroxy-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol

4-methoxyphenyl magnesium bromide

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

(R)-2-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-phenyl)-methoxy]-propionic acid ethyl ester

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