3,4,4-Trimethyl-pentanoic acid phenylamide

Base Information

• Chemical Name: 3,4,4-Trimethyl-pentanoic acid phenylamide
• CAS No.: 74973-28-7
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.327
• Mol file: 74973-28-7.mol

Synonyms:3,4,4-Trimethyl-pentanoic acid phenylamide

Chemical Property of 3,4,4-Trimethyl-pentanoic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,4-Trimethyl-pentanoic acid phenylamide

There total 3 articles about 3,4,4-Trimethyl-pentanoic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-crotonanilide (17645-30-6) + tert.-butyl lithium (594-19-4) → 3,4,4-Trimethyl-pentanoic acid phenylamide (74973-28-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)92805-3

Reference yield: 66.0%

crotonanilide (1733-40-0) + tert-butylmagnesium chloride (677-22-5) → 3,4,4-Trimethyl-pentanoic acid phenylamide (74973-28-7)

Guidance literature:

With methyllithium; In tetrahydrofuran; diethyl ether; at -10 ℃; for 1h;

DOI:10.1246/cl.2007.736

Reference yield: 52.0%

(E)-crotonanilide (17645-30-6) + pivalaldehyde (630-19-3) → 3,4,4-Trimethyl-pentanoic acid phenylamide (74973-28-7)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; water; sodium bromide; In acetone; at 20 ℃; for 48h; Inert atmosphere; Irradiation;

DOI:10.1002/adsc.202101188

upstream raw materials:

(E)-crotonanilide

tert.-butyl lithium

crotonanilide

tert-butylmagnesium chloride