N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1416335-15-3
Molecular Formula:C₂₇H₃₀F₂N₆O₄S
Molecular Weight:572.636
Hs Code.:

N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Synonyms:N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Suppliers and Price of N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 8 articles about N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.29%

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1416337-01-3
6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

: 1416335-15-3
N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 3h;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1416335-15-3
N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium dithionite / ethanol; water / 20 °C

3: methanol / 20 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 90 °C

With sodium dithionite; potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

: 152684-30-5
5-bromo-2-methoxy-3-nitropyridine

: 1416335-15-3
N-[5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / acetic anhydride / 3 h / Reflux

2: pyridine / 20 h / 20 °C

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux; Inert atmosphere

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 90 °C

With pyridine; tin(II) chloride dihdyrate; potassium acetate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetic anhydride; 3: Suzuki Coupling / 4: Suzuki Coupling;